WISENERVE PLUS

Each Soft Gelatin Capsules Contains:

• Methylcobalamin-1500 mcg;
• Alpha Lipoic Acid – 200 mg
• Selenium -55 mcg
• Chromium Picolinate-200 mcg
• Zinc Sulphate-27.5 mg
• Inositol - 100 mg
• Folic Acid - 1. 5 mg

Alpha Lipoic Acid :

Lipoic acid, also known as α-lipoic acid and Alpha Lipoic Acid (ALA) is an organosulfur compound derived from octanoic acid. Alpha-lipoic acid is a naturally occurring compound that is synthesized by plants and animals, including humans. Lipoic acid is a ''non-vitamin" nutrient that is essential to life. Lipoic acid is found in almost all foods, but slightly more so in kidney, heart, liver, spinach, broccoli, and yeast extract. It is not classified as a vitamin because it is produced in the body. It is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for organisms. Alpha-lipoic acid is a disulfide compound that is a cofactor in vital energy-producing reactions in the body. The body appears to be able to manufacture enough alpha-lipoic acid for its metabolic functions, but the excess levels provided by supplements allow alpha-lipoic acid to circulate in a free state. Naturally occurring lipoic acid is always covalently bound and not immediately available from dietary sources. Additionally, the amount of lipoic acid present is very low. ALA was shown to be hepatoprotective, to improve liver circulation, and treat chronic liver diseases, including jaundice, hepatitis, cirrhosis, and hepatic coma, to treat diabetes, and diabetic neuropathy to alter carbohydrate metabolism, histidine metabolic disorders, blood pyruvate and lactate levels, to treat psychiatric diseases, Botkin’s disease, antimony poisoning, mercury poisoning, atherosclerosis, coronary atherosclerosis, cerebrovascular diseases, ethionine-damaged liver potassium cyanide poisoning, streptomycin intoxication, mushroom poisoning, lower cholesterol, reverse barbiturate anaesthesia, experimentally reduce voluntary alcohol intake, and augment potassium tolerance .One of the most studied clinical uses of ALA is the treatment of diabetes and diabetic neuropathy.ALA has also been used to prevent organ dysfunction, reduce endothelial dysfunction and improve albuminuria, treat or prevent cardiovascular disease, accelerate chronic wound healing, reduce levels of ADMA in diabetic end-stage renal disease patients on haemodialysis, burning mouth syndrome, reduce iron overload, treat metabolic syndrome, improve or prevent age-related cognitive dysfunction, prevent or slow the progression of Alzheimer’s Disease, prevent erectile dysfunction, prevent migraines, treat multiple sclerosis, treat chronic diseases associated with oxidative stress reduce inflammation, inhibit advanced glycation end products (AGE), treat peripheral artery disease.

Antioxidant and pro-oxidant effects of lipoic acid and dihydrolipoic acid

The antioxidant effects of ALA were demonstrated when it was found to prevent the symptoms of vitamin C and vitamin E deficiency. ALA is reduced intracellularly to dihydrolipoic acid, which in cell culture regenerates by reduction of antioxidant radicals, such as vitamin C and vitamin E.ALA is able to scavenge reactive oxygen and reactive nitrogen species in vitro due to long incubation times, but there is little evidence this occurs in vivo or that radical scavenging contributes to the primary mechanisms of action of ALA. The relatively good scavenging activity of LA toward hypochlorous acid (a bactericidal produced by neutrophils that may produce inflammation and tissue damage) is due to the strained conformation of the 5-membered dithiolane ring, which is lost upon reduction to DHLA. In cells,ALA is reduced to dihydrolipoic acid, which is generally regarded as the more bioactive form of LA and the form responsible for most of the antioxidant effects.

USES :

Alpha-lipoic acid helps to neutralize the effects of free radicals on the body. Free radicals are waste products the body creates when food is turned into energy. The body can use some free radicals, but too many can reduce immunity needed to fight infection, cancer, and heart disease. Alpha-lipoic acid works together with other antioxidants such as vitamins C and E. It is important for growth, helps to prevent cell damage, and helps the body rid itself of harmful substances.

Alpha-lipoic acid supplements hold promise for treating various disorders, including HIV infection, liver ailments, and glaucoma. Lipoic acid shows evidence of being effective in the treatment of diabetic neuropathy and may be useful in treating some other aspects of diabetes. In addition to functioning as an antioxidant, this hard-working nutrient assists the B vitamins in producing energy from the proteins, carbohydrates, and fats consumed through foods.

Peripheral neuropathy is a type of nerve damage that may result in decreased sensitivity, numbness, and pain, particularly in the lower extremities. Alpha-lipoic acid may help to block such damage. Because of its effect on glucose metabolism, lipoic acid may improve the glucose-lowering action of insulin. In conjunction with other antioxidants, such as vitamin E, alpha-lipoic acid may be doubly helpful in patients with diabetes. Oxidative stress has been implicated in the pathology of diabetic neuropathy, and alpha-lipoic acid is approved for the treatment of diabetic neuropathy in Germany.

Alpha-lipoic acid may improve long-term memory. Because alpha-lipoic acid can pass easily into the brain, it has protective effects on brain and nerve tissue and shows promise as a treatment for stroke and other brain disorders involving free radical damage. As an antioxidant, alpha-lipoic acid holds promise for protecting the body against changes in healthy cells that lead to cancer. The evidence for this cancer-preventive effect is still preliminary, however. Alpha-lipoic acid may benefit anyone whose limbs tend to tingle or become numb, or "fall asleep" due to nerve compression.

Alpha-lipoic acid may prove useful in the treatment of chronic hepatitis because it relieves stress on the liver and helps rid the body of toxins. As an antioxidant, alpha-lipoic acid shields the liver from potentially harmful cell changes and assists it in flushing toxins from the body. This makes it useful in treating such liver disorders as chronic hepatitis and cirrhosis.

RECOMMEDED DOSAGE:

Alpha-lipoic acid dosage, intake, recommended daily allowance (RDA)

Currently there are no established recommended doses for supplementation. For use as a general antioxidant, a lower dosage of 20 to 50 mg daily is commonly recommended. Recommendations for the use of racemic alpha-lipoic acid as an antioxidant range from 50 mg/day to 400 mg/day. The typical dosage of oral lipoic acid for treating complications of diabetes is 300 to 600 mg daily. Alpha-lipoic acid can be purchased in dosages ranging 30 mg to 100 mg tablets.

Methylcobalamin :

Methylcobalamin is a form of vitamin B12. All vitamin B12 compounds are soluble in water, and naturally occurring forms of B12 — such as methylcobalamin — are produced by bacteria. These bacteria are present in the human liver, but the cobalamin compounds produced there are not usable by the body, and are flushed out with faeces. In order to obtain the required amount of vitamin B12 from dietary sources, humans must consume animal products. Plants produce a compound similar in structure to B12, but that actually inhibits B12 activity in humans. A lack of vitamin B12 in the body leads to pernicious anaemia, a condition that inhibits DNA replication. It also causes low blood pressure, minor cognitive impairment, and jaundice. Pernicious anaemia is also known as Addison–Biermer anaemia.There is also a rare genetic disorder known as Arakawa's syndrome II, which causes a deficiency in the enzyme necessary to metabolize methylcobalamin. This disorder leads to the same symptoms as pernicious anaemia. Arakawa’s syndrome II is a dominant autosomal disorder, which means that only copy of the defective gene in a body is required for the methylcobalamin metabolizing enzyme to cease functioning. Methylcobalamin (methyl B12) is the neurologically active, most bio available and best-utilized form of vitamin B12. Methyl B12 is more effective than traditional forms of B12 for treating pernicious anaemia (B12 deficiency) as there is no need for conversion by the body and is better retained by the liver and other tissues. Clinical studies have documented the efficacy of methyl B12 in slowing down or even reversing the effects on nerve tissue. Methyl B12 also appears to play a role in balancing brain chemicals and synthesizing neurotransmitters, which are the chemical means of communication between nerve cells. Studies also demonstrate B12's ability to reduce high homocysteine serum levels, which have been linked to arterial injury. Methyl B12 has exhibited beneficial effects against brain aging, irregular sleep patterns and reducing high homocysteine serum levels. It may also support immune function, and promote normal cell growth. Methyl B12 represents one of the best values in nutritional products, given its comparably low cost and its wide range of potential benefits. Methyl B12 is The Superior Form of Vitamin B12. Of the six structurally related compounds generically termed vitamin B12, methyl B12 possesses numerous distinct advantages: Methycobalamin is also safer than cyanocobalamin, which contains trace amounts of cyanide. 100% Active Coenzyme Methyl B12 is one of only two forms of vitamin B12 that is in an active, coenzymated state (the other being adenosylcobalamin). Most other cobalamin forms can be converted to coenzymes, but the process is inefficient. In fact, in order for ordinary vitamin B12 to be activated and ready for methyl donation, it must first be converted to methylcobalamin by S-Adenosylmethionine (aka SAMe), an important intermediate metabolite.

The RDI for adolescents and adults is 6 mcg per day. Clinical trials have used up to 6,000 mcg daily.

Selenium :

Selenium is a powerful antioxidant essential for the body. Selenium enhances the mobility of sperms, which is important for fertilization. Sperms need to be capable of swimming to the egg to imp regnant the woman's egg. Men who have sperm with low mobility rates can be due to the tail of the sperm breaking off causing it to be immobile. The mineral selenium can strength the tails in order to prevent breakage. Selenium is essential in the detoxification of toxic metals in the human system, foetal respiration and energy transfer reactions as well as in the production of sperm cells. Selenium deficiency in the testicular tissues induces degeneration which results in the active impairment of sperm motility as the first indication of impending infertility.

Chromium Picolinate :

Chromium is an essential nutrient required for normal sugar and fat metabolism and works primarily by potentiating the action of insulin. It is present in the entire body but with the highest concentrations in the liver, kidneys, spleen and bone. Chromium picolinate is the chemical compound that is sold as a nutritional supplement to prevent or treat chromium deficiency.

This bright-red coordination complex is derived from chromium and picolinic acid. Small quantities of chromium are needed for glucose utilization by insulin in normal health, but deficiency is extremely rare and has only been observed in hospital patients on long-term defined diets.Chromium picolinate is effective in improving glycemic control and normalizing lipid levels in people with type 2 diabetes.USES:Chromium is needed for energy, maintains stable blood sugar levels. In cooperation with other substances, it controls insulin as well as certain enzymes. It works with GTF (Glucose Tolerance Factor) when this hormone-affiliated agent enters the bloodstream because of an increase of insulin in the bloodstream. GTF (containing niacin, vitamin B3, glycine, cysteine, glutamic acid etc.) enhances insulin, which results in the sugars passing quicker into the cells and in that way they are removed from the bloodstream. By stabilizing the blood sugar level it also assists in regulating the cholesterol in the blood. Natural chromium levels decline with age and so with the action of the GTF. Although chromium picolinate is readily absorbed by the body, and is one of the best types of chromium when it comes to absorption, it will only be absorbed it if there is a shortage of chromium. Chromium picolinate has been used as a carbohydrate-burning supplement for some time and has proved very successful. (Chromium picolinate is chromium chelated with picolinate - a natural amino acid metabolite) It is also required in synthesis of fats, protein and carbohydrates, and may assist in preventing coronary artery disease.

Zinc :

Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues.Zinc sulfate is used to treat and to prevent zinc deficiency.

Inositol :

Inositol (Inositol hexaniacinate) is a nutrient that works with vitamin B compounds to serve several functions in the body. Inositol is mainly being used to treat mental disorders . These include depression, obsessive-compulsive disorder, bipolar, and anxiety. It has also been shown to help women suffering from polycystic ovarian disease, as well as men and women suffering from non-scarring alopecia, commonly referred to as baldness. It has also been tested on patients suffering from smoke-related cancers, but with little success. Inositol helps control cholesterol, prevents Reynaud's syndrome, helps treat depression, and helps combat diseases associated with aging, such as arthritis and diabetes. Inositol increases liver function, reduces hypertension. It also can reduce muscle cramping by promoting oxygen flow to sore muscles. Inositol protects the heart and the liver, prevents kidney stones, slows cancerous tumor growth, reduces cholesterol, and inhibits the formation of blood clots. It also enhances the function of the immune system, which helps people undergoing chemotherapy and radiation treatments remain healthy. Inositol compounds are found in many foods, including beans and legumes, brown rice, whole-kernel corn, sesame, grape juice, and raisins.

Folic Acid :

Folic acid is a B COMPLEX vitamin. It is necessary for the production of red blood cells and normal metabolism. It is an important vitamin for pregnant women as it can prevent the occurrence of birth defects and prevents infant spinal cord defects like Spina bifida. Folic acid may also help other conditions such as depression, schizophrenia, arthrosclerosis, heart disease, and diarrhea. It can also be helpful in treating epilepsy gingivitis, gout, and cancer.

INDICATION

• PRGENANCY & LACTATION
  
  
• POST MENOPAUSE SYNDROME
  
  
• POST HYSTERECTOMY
  
  
• INFERTILITY
  
  
• CONVALASCENCE
  
  
• MEGALOBLASTIC ANAEMIA
  
  
• DIABETIC NEURPOATHY
  
  
• PERIPHERAL NEUROPATHY
  
  
• DIABETIC NEPHROPATHY
  
  
• ALCHOLIC NEUROPATHY
  
  
• DRUG INDUCED NEUROPATHY
  
  
• CRANIAL NEUROPATHY