CALCO-Q

EACH SOFT GELATIN CAPSULE CONTAINS

ANTIOXIDANTS

An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions that damage cells. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often reducing agents such as thiols, ascorbic acid or polyphenols. Although oxidation reactions are crucial for life, they can also be damaging; hence, plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Low levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells. As oxidative stress might be an important part of many human diseases, the use of antioxidants in pharmacology is intensively studied, particularly as treatments for stroke and neurodegenerative diseases. However, it is unknown whether oxidative stress is the cause or the consequence of disease. Antioxidants are widely used as ingredients in dietary supplements in the hope of maintaining health and preventing diseases such as cancer, coronary heart disease and even altitude sickness.

LYCOPENE :

Lycopene is a bright red carotene and carotenoid pigment and phytochemical found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons and papayas. Lycopene may be the most powerful carotenoid quencher of singlet oxygen, being 100 times more efficient than vitamin E, which in turn has 125 times the quenching action of glutathione (water soluble). Singlet oxygen produced during exposure to ultraviolet light is a primary cause of skin aging. Given its antioxidant properties, substantial scientific and clinical research has been devoted to a possible correlation between lycopene consumption and general health.

Early research suggested some amelioration of cardiovascular disease, cancer, diabetes, osteoporosis, and even male infertility. Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals. It is found in high concentrations in the testes and seminal plasma and decreased levels have been demonstrated in men suffering from infertility. Oral Lycopene provided excellent results in idiopathic male infertility. Maximum improvement seems to occur in the sperm concentration (66% cases).

ZINC SULPHATE :

Zinc is an essential mineral essential for proper functioning of body and it is second only to iron among the trace elements in the human body. It is distributed throughout the body with highest concentrations in the liver, pancreas, kidney, bone, muscles, eye, prostate, spermatozoa, skin, hair and nails. Zinc participates in metabolic reactions to synthesize or degrade carbohydrates, proteins, fats and nucleic acids. Zinc supports proteins functioning in many metabolic processes including stabilizing cell membranes and supporting immune function, growth and development .Zinc deficiency can lead to many disorders. Zinc is a wide-ranging mineral and it contains over 200 of the body's enzymes. Semen and its constituents generally contain a high volume on the mineral. Zinc deficiency leads to decreased numbers of sperm and impotence in men. Folic Acid and Zinc significantly increased the sperm concentration in sub fertile men. Zinc is critical to male reproduction potential. The concentration of zinc in semen is high. Zinc in seminal fluid appears to protect sperm from bacteria and chromosomal damage. Zinc is important for the cell division and the production of healthy sperm. It is the most Critical trace mineral for male sexual function. It is needed for testosterone metabolism, testicle growth, sperm production, motility, count, reducing excess estrogen in male reproductive tissue.

FOLIC ACID

Folic acid (also known as vitamin B9 or folacin) and folate (the naturally occurring form), as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroyl monoglutamic acid are forms of the water-soluble vitamin B9. Folic acid is itself not biologically active, but its biological importance is due to tetrahydrofolate and other derivatives after its conversion to dihydrofolic acid in the liver. Folic acid affects male infertility in such a way that it helps to reduce breaks in the chromosomes of the male. This reduction of breaks encourages the multiplication of the number of sperm cells in an individual male who might suffer from partial infertility. The supplementation of folic acid and male infertility issues are effectively addressed because the vitamin helps in spermatogenesis or the generation of multitudes of sperm cells.

SELENIUM :

Selenium is a powerful antioxidant essential for the body. Selenium enhances the mobility of sperms which is important for fertilization. Sperms need to be capable of swimming to the egg to impregnate the woman's egg. Men who have sperm with low mobility rates can be due to the tail of the sperm breaking off causing it to be immobile. The mineral selenium can strength the tails in order to prevent breakage.

Selenium is essential in the detoxification of toxic metals in the human system, foetal respiration and energy transfer reactions as well as in the production of sperm cells. Selenium deficiency in the testicular tissues induces degeneration which results in the active impairment of sperm motility as the first indication of impending infertility.

UBIDECARENONE(COENZYME Q-10) :

Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney —have the highest CoQ10 concentrations. CoQ10 is well known free radical scavenger. Free radicals cause oxidative damage in various chronic disease states like atherosclerotic heart disease, hypertension, congestive heart failure, diabetes mellitus, ischaemia reperfusion injury, dyslipidaemia and many other conditions.

Three important parameters in infertility are count, morphology and motility of sperm cells. The sperm count and morphology may be adversely affected due to damage by free radicals. The reduced sperm motility is the consequence of decrease in energy production ATP. CoQ10 has been found to be useful in idiopathic asthenozoospermia, which is loss or decrease of sperm motility in semen. Testicular tissue and sperm viability are particularly vulnerable to peroxidation injury produced by free radicals and reactive oxygen species. Increased lipid peroxidation of sperm leads to its damage and thereby causing infertility. The reasons why sperms are vulnerable to damaging effects of these are: wide surface of the sperm membranes, poor cytoplasmic defence mechanisms, lack of protection in the female genital tract once the sperms are ejaculated.

L-ARGININE :

Arginine (L-Arginine) is an amino acid. The L-form is one of the 20 most common natural amino acids. L-Arginine plays an important role in cell division, the healing of wounds, removing ammonia from the body, immune function, and the release of hormones. L-Arginine has also been reported to improve erectile dysfunction significantly. Arginine is an amino acid that the body cannot make naturally. Therefore it is important to consume foods that are rich in arginine. L-Arginine amino acids are found in high concentrations in nuts and seeds like peanuts and almonds. L-Arginine amino acid is necessary for the execution of many physiological processes. These physiological processes include hormone secretion, an increase in growth hormone output, the removal of toxic waste products from the body, and immune system defences.

L arginine improves sperm count and quality in infertile men.

Dosage :

1-2 capsules TWICE DAILY as directed by the physician.

Indications :

• Oligospermia
• Asthenzoospermia
• Teratozoospermia